The UNODC World Drug Report 2025 reveals that over 300 million people used drugs last year, with 600,000 annual deaths due to addiction. The drug problem is evolving, with synthetic drugs spreading rapidly among younger users and moving into digital spaces. An international forum in Samarkand discussed these issues, highlighting Uzbekistan's commitment to combat drug trafficking through legislation and national strategies. The drug trade in Central Asia is changing, with a decline in opium production and an increase in methamphetamine labs. Criminal networks are adapting, using AI and cryptocurrencies, making detection harder. Uzbekistan is enhancing cooperation and prevention efforts, focusing on community awareness and healthcare.