The main challenges in global health for this year include shifts in global health leadership, climate change, AI in healthcare, funding cuts to humanitarian aid, rising child mortality, and workforce shortages. Experts emphasize the need for integration and country leadership in health initiatives, while also highlighting the potential of AI and biotechnology to transform healthcare. Climate change poses new health threats, and the pharmaceutical sector faces geopolitical tensions. There is hope for addressing the gender health gap and preventing neglect in public health.